Full-size CIPSIP Bioreactors 150L
A Product by SYSBIOTECH SARL Company
OverviewSpecificationsResources

Full-size CIP/SIP Bioreactors 150L-300L-500L

SYSBIOTECH Pilot-scale Bioreactor is a reliable solution for working with cell culture-based process for scientific research and small biotech production facilities, as well as for scaling-up technology.

Standard «ready to use» solutions include all components needed for convenient operation with cell culture applications. After connecting the Bioreactor you can start using it right away without having to buy any accessories.

SYSBIOTECH Pilot-scale Bioreactors have fully aseptic design and can be validated easily. C-BIO2 control system, universal for any volume of Bioreactor greatly simplifies scale-up process and allows for easy transfer of cultivation data.

If needed, SYSBIOTECH Bioreactors can be upgraded to fulfill your specific application requirements.

For your convenience, all the necessary piping is installed on open stainless steel mobile frame. This helps to save space in your facility and simplifies access for maintenance of the Bioreactor.

All wetted surfaces are made of AISI 316L stainless steel with surface finish of 0.4 μm, to allow for effective CIP (cleaning-in-place).

Automated and user-configurable CIP and SIP (cleaning-in-place and sterilization-in-place) processing is standard included. A user-friendly program tool allows you to create your CIP and/or SIP sequence by defining its steps and set parameters. By combining sequences you can build a fully automated procedure for your entire application, maximizing day to day process consistency and ensuring best results.

Vessel (Height/Diameter: 1.5/1)
Total volume 150L/300L/500L
Working volume 105L/210L/350L
Materials AISI 316L for wetted parts
AISI 304L for non-wetted parts
Design pressure 3.0 kg/cm3 (vessel)
4.0 kg/cm3 (jacket)
Design temperature 143°С (vessel)
151°С (jacket)
Surface finish Ra 0,4 μm (electropolished)
External polishing Ra 1.2 μm
Components:
Top lid Diaphragm Pressure Gauge
Diaphragm Pressure Transmitter
Rupture disk with outlet pipe
Gases exhaust with condensor
Inoculation
Light glass
Foam control with peristaltic pump
CIP spray ball
Upper side walls Air inlet
Viewing glass
Addition inlet
Sparger (ring or micro sparger)
Lower side walls Temperature sensor PT100
pH control with peristaltic pumps
pO2 sensor
Sterile sampling system
Different sensors available on request: optical density, ORP, level, weight, conductivity, pCO2
Jacket Steam inlet / Cooled water outlet
Steam outlet / Cooled water supply (with safety valve and manometer)
Bottom Sterializable bottom valve
Agitation unit Mechanical or magnetic seal
Manual/automatic speed control depending on the amount of dissolved oxygen.
Speed range 20-200 RPM. Maximum speed calculated according application
Different impeller types available on request
3 welded baffles
Aeration unit Automatic air O2, CO2 supply
5" absolute filter 0,2 μm and filter housing made from AISI 316L stainless steel
Manual flow meter or automatic MFC (mass flow controller)
Piping Material Sanitary grade steel
Piping construction Air supply
Plant steam supply
Pure steam supply
Cooling water supply
Cooling water return
Waste water drain
Waste liquid drain
Waste gas out
Fittings Diaphragm valve
Angle seat valve
Steam trap
Diaphragm pressure gauge
Ball valve and Pneumatic angle valve
Check valve
Safety valve
Pipes welding Orbital welding (product line)
Manual welding (general line)
features:
  • Ready-to-work standard solutions with the ability to upgrade.
  • 100% aseptic design, easy validation.
  • Different types of impellers: Rushton, marine-blade, pitched-blade right- and left-handed orientation with radial or axial flow.
  • Motor with single mechanical or magnetic seal guarantees 100% aseptic operation.
  • Mixing speed 30–600 rpm (standard option); up to 1,500 rpm upon request.
  • Standard sensors: temperature, pH, pO2, and foam.
  • Sensors upon request: OD, ORP, level, weight, conductivity, pCO2, gas analyzers.
  • 5" absolute filters 0.2 μmto ensure purity of gas mixture inside the vessel.
  • Manual flow meter or automatic mass flow controller (MFC) to regulate supply of gas mixture.
  • Different sparger types including ring- or micro-spargers. Various specific designs are available upon request.
  • Two in-gold ports for housing any required electrodes.